RedShiftBio at PEGS Boston 2024

RedShiftBio has long been a proud sponsor of PEGS Boston and is solidly committed to its community.

Now in its 20th year, PEGS promises a forum for researchers and solutions providers to once again meet and partner toward advancing the future of biotherapeutic drug development.

Meet the RedShiftBio team at Booth 801 to learn about our very latest advances in Microfluidic Modulation Spectroscopy and innovations in bioprocessing made possible by purpose-built chromatography. We will have our flagship system, Aurora, and trailblazing HaLCon Protein Analyzer on display as well as some other surprises to help commemorate this auspicious year for the PEGS community and some of the new contributions we are making in the world of biopharma development and manufacturing.

Poster Presentation: 

Structural Characterization of RNA and Detection of RNA-ligand Binding Using Microfluidic Modulation Spectroscopy (MMS)

Presented by Valerie I. Collins, PhD

Abstract:  
Riboswitches are small, well-folded mRNA sequences that control the translation of specific mRNA segments for regulation of protein production. Each riboswitch has a unique small molecule that induces structural changes upon binding and results in activation of the riboswitch. In this study, we used X-ray crystallography data from the literature and MMS to characterize the structural changes associated with ligand binding and determine the apparent dissociation constant, Kd. MMS provides a better overall understanding of not only binding affinity, but also structural change associated with binding. This technique can be useful in the development of novel small molecular regulators of RNA for therapeutic purposes.

Session C6B: Biophysical Methods