RedShiftBio at PEGS Boston 2025

Instroduction:

Meet the RedShiftBio team at Booth 33 to learn about our very latest capabilities for determining protein stability and structure in one measurement using microfluidic modulation spectroscopy. Aurora TX can analyze mAbs, proteins, peptides, and even RNA/DNA for structure, stability, concentration, and similarity all with the simple push of a button. IR Spectroscopy has never been this easy!

Poster Number: B083

Determining Protein Stability and Structure in One Measurement using Microfluidic Modulation Spectroscopy (MMS).

Presented by: Valerie Collins, PhD

Abstract:

Protein stability is a critical quality attribute for protein therapeutics and melting temperature (Tm) is most-often used for ranking candidates. Historically, Tm is measured using DSF, DSC, or CD. However, these techniques are one-dimensional and will only give you the Tm. Here we introduce Microfluidic Modulation Spectroscopy thermal ramping to determine not only the melting temperature, but also the protein structure at each temperature, yielding a much more data-rich analysis.