Seeing What Other Methods Miss: Peptide Structure and Stability in Formulation by MMS
Overview:
This webinar demonstrates how Microfluidic Modulation Spectroscopy (MMS), implemented on the Aurora TX, enables detailed characterization of peptide structure and stability that conventional biophysical techniques often miss. Using IR-based secondary structure analysis, MMS quantifies alpha-helix, beta-sheet, turn, and unordered content across formulation buffers, solvents, and temperature ramps—while remaining compatible with excipients, salts, and organic solvents.
Through multiple real-world case studies, including GLP-1 analogs, immunogenic peptides from different manufacturing processes, and cyclic peptides, the presentation highlights MMS’s ability to detect subtle aggregation pathways, formulation-induced conformational changes, shelf-life effects, and cyclization differences. These insights support formulation development, process quality control, and stability assessment—providing a fast, sensitive, and structure-aware alternative to CD, DSC, DSF, and DLS.
Speakers:
- Scott Gorman | Application Scientist, RedShiftBio
