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App Notes

App Notes

Secondary Structure Analysis: Using Microfluidic Modulation Spectroscopy to Determine the Structural Effect of pH on the Peptide Hormone Insulin

December 1, 2020

APPLICATION NOTE

This Application Note Includes:

  • Determines the structural effects of low pH on insulin using MMS
  • Measures protein secondary structure by combining infrared spectroscopy
    with microfluidics to enhance sensitivity and accuracy
  • Achieves higher sensitivity across a wider concentration range compared
    to current FTIR techniques

Protein Analysis Tools: Characterizing Secondary Structure Analysis Of Insulin

Secondary structure characterization is an essential part of drug development, however, the tools for measuring secondary structure of small proteins and peptides are limited. Microfluidic Modulation Spectroscopy (MMS), a new characterization platform that powers the AQS³pro system developed by RedShiftBio, measures protein secondary structure by combining infrared spectroscopy with microfluidics to enhance sensitivity and accuracy.

Insulin is the test subject for this study demonstrating the ability of MMS to determine structural effects of low pH.

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