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App Notes

App Notes

Rapid and Accurate Determination of the Higher Order Structure of a Library of Proteins Using Microfluidic Modulation Spectroscopy

March 3, 2023

This app note studies the higher order structure (HOS) of eight different proteins with a variety of secondary structures: Hemoglobin, BSA, Lysozyme, Cytochrome C, IgG, Carbonic anhydrase,  Chymotrypsinogen A, and Chymotrypsin A, and then compares the results to structural data obtained by FTIR, X-ray crystallography and AlphaFold.

Learn why MMS is a reliable method to obtain protein structural information that concurs with these other techniques while requiring only a fraction of the time and effort to generate. The repeatability of measurements for these different proteins at 10 mg/mL is consistently over 99.8%, and over 98% for samples at 1 mg/mL, providing an extreme level of confidence for formulation groups that need to generate high-quality data for their drug products at high concentrations. In addition, this data expands the protein database (protein library) in our MMS delta software for a wider variety of protein samples to choose from.

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