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The Evolution of Spectroscopy: A New Technique for Biotherapeutic Formulation

November 1, 2018

American Laboratory

Eugene Ma, Brent Kendrick, and Libo Wang

The structural characterization of biopharmaceuticals is typically performed using traditional spectroscopic methods such as Fourier transform infrared (FTIR) and circular dichroism (CD). These techniques, however, are not optimal for protein product development, particularly with respect to performing the measurement at the formulated concentration. A new technique for characterizing the secondary structure of proteins that is uniquely well-matched to the demanding requirements of biotherapeutic development, Microfluidic Modulation Spectroscopy (MMS)(RedShiftBio, Burlington, MA) has the ability to measure with high sensitivity across an extremely wide concentration range.

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